Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic
نویسندگان
چکیده
منابع مشابه
Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic.
Structural maintenance of chromosomes (SMC) protein complexes, including cohesin and condensin, play key roles in the regulation of higher-order chromosome organization. Even though SMC proteins are thought to mechanistically determine the function of the complexes, their native conformations and dynamics have remained unclear. Here, we probe the topology of Smc2-Smc4 dimers of the S. cerevisia...
متن کاملThree-dimensional topology of the SMC2/SMC4 subcomplex from chicken condensin I revealed by cross-linking and molecular modelling
SMC proteins are essential components of three protein complexes that are important for chromosome structure and function. The cohesin complex holds replicated sister chromatids together, whereas the condensin complex has an essential role in mitotic chromosome architecture. Both are involved in interphase genome organization. SMC-containing complexes are large (more than 650 kDa for condensin)...
متن کاملNesprin-2 Interacts with Condensin Component SMC2
The nuclear envelope proteins, Nesprins, have been primarily studied during interphase where they function in maintaining nuclear shape, size, and positioning. We analyze here the function of Nesprin-2 in chromatin interactions in interphase and dividing cells. We characterize a region in the rod domain of Nesprin-2 that is predicted as SMC domain (aa 1436-1766). We show that this domain can in...
متن کاملThe Condensin Complex Governs Chromosome Condensation and Mitotic Transmission of Rdna
We have characterized five genes encoding condensin components in Saccharomyces cerevisiae. All genes are essential for cell viability and encode proteins that form a complex in vivo. We characterized new mutant alleles of the genes encoding the core subunits of this complex, smc2-8 and smc4-1. Both SMC2 and SMC4 are essential for chromosome transmission in anaphase. Mutations in these genes ca...
متن کاملTargeting condensin, a vital spot of MYCN-amplified neuroblastoma
Neuroblastoma is a disease in which malignant cells form in nerve tissue. Amplification of MYCN, a member of the MYC proto-oncogene family, is frequently observed in neuroblastoma, and it is associated with malignant phenotype and poor prognosis.1 in the April 1, 2014 issue of Cell Cycle, Murakami-Tonami et al.2 reported that downregulation of sMC2, a subunit of condensin, leads to cell death t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Reports
سال: 2016
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2016.01.063